BAG3 - BAG family molecular chaperone regulator 3 - human protein (Function)
 
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BAG3 »  BAG family molecular chaperone regulator 3  (BAG-3)
 
Protein also known as:  Bcl-2-associated athanogene 3.
Gene name:  BAG3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.  
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IDAMGI
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • NASUniProtKB
Negative regulation of striated muscle cell apoptotic processdefinition[GO:0010664] silver  
  • IEAOrtholog Compara
Protein foldingdefinition[GO:0006457]  
1
  • NASUniProtKB
Protein stabilizationdefinition[GO:0050821] silver  
  • IEAOrtholog Compara
Spinal cord developmentdefinition[GO:0021510] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAG3
GenomeRNAi: 9531
PRO: PR:O95817