MAP4K4 - Mitogen-activated protein kinase kinase kinase kinase 4 - human protein (Function)
 
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MAP4K4 »  Mitogen-activated protein kinase kinase kinase kinase 4   [ EC 2.7.11.1 ]
 
Protein also known as:  MAPK/ERK kinase kinase kinase 4 (MEKKK 4).
Gene name:  MAP4K4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 83 5
GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Creatine kinase activitydefinition[GO:0004111] silver  
1
  • CACAO
Not  MAP kinase kinase kinase kinase activitydefinition[GO:0008349]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • RefGenome
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • RefGenome
Not  Microvillus assemblydefinition[GO:0030033]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • CACAO
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of JNK cascadedefinition[GO:0046328]  
1
  • UniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • RefGenome
Stress-activated protein kinase signaling cascadedefinition[GO:0031098]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+9448  
According to Reactome, this protein belongs to the following pathway:
Oxidative Stress Induced Senescence  R-HSA-2559580  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP4K4
GenomeRNAi: 9448
PRO: PR:O95819
Chemistry
GuidetoPHARMACOLOGY: 2088