MAP4K4 - Mitogen-activated protein kinase kinase kinase kinase 4 - human protein (Function)
 
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MAP4K4 »  Mitogen-activated protein kinase kinase kinase kinase 4
 
Gene name:  MAP4K4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Small GTPase regulator activitydefinition[GO:0005083] silver  
  • IEAInterPro 2 GO
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
  • IEAInterPro 2 GO
Regulation of JNK cascadedefinition[GO:0046328]  
1
  • IDAUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+9448  
According to Reactome, this protein belongs to the following pathway:
Oxidative Stress Induced Senescence  REACT_169436  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP4K4
GenomeRNAi: 9448
PRO: PR:O95819
Chemistry
GuidetoPHARMACOLOGY: 2088