AIFM1 - Apoptosis-inducing factor 1, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
AIFM1 »  Apoptosis-inducing factor 1, mitochondrial   [ EC 1.1.1.- ]
 
Protein also known as:  Programmed cell death protein 8.
Gene name:  AIFM1
Entry whose protein(s) existence is based on evidence at protein level
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1 109 6
GENE REF ISO

Function

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Overview 
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. Caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.  
4
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Electron carrier activitydefinition[GO:0009055]  
1
  • TASPINC
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
NAD(P)H oxidase activitydefinition[GO:0016174]  
1
  • TASUniProtKB
Oxidoreductase activity, acting on NAD(P)Hdefinition[GO:0016651]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAUniProtKB
Apoptotic DNA fragmentationdefinition[GO:0006309] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • IMPUniProtKB
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Chromosome condensationdefinition[GO:0030261]  
1
  • TASUniProtKB
DNA catabolic processdefinition[GO:0006308]  
1
  • TASUniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
  • ISSOrtholog Curator
Isoforms  Iso 1 and Iso 3   Mitochondrial respiratory chain complex I assemblydefinition[GO:0032981]  
1
  • IMPUniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Isoform  Iso 3   Neuron differentiationdefinition[GO:0030182]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • TASUniProtKB
Enzymatic activity 
It requires the following cofactor
FAD.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+9131  
Glutathione metabolism  hsa00480+51060  
 

Biophysicochemical properties

Kinetic parameters
KM 1.53 mM for NADH
KM 26 uM for cytochrome c

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AIFM1
GenomeRNAi: 9131
PRO: PR:O95831