AIFM1 - Apoptosis-inducing factor 1, mitochondrial - human protein (Function)
 
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References

 
AIFM1 »  Apoptosis-inducing factor 1, mitochondrial   [ EC 1.1.1.- ]
 
Protein also known as:  Programmed cell death protein 8.
Gene name:  AIFM1
Entry whose protein(s) existence is based on evidence at protein level
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1 116 6
GENE REF ISO

Function

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Overview 
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. Caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.  
5
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • Ortholog Compara
Electron carrier activitydefinition[GO:0009055]  
1
  • PINC
FAD bindingdefinition[GO:0071949] silver  
1
  • Ortholog Compara
NAD(P)H oxidase activitydefinition[GO:0016174]  
1
  • UniProtKB
Oxidoreductase activity, acting on NAD(P)Hdefinition[GO:0016651]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • UniProtKB
Apoptotic DNA fragmentationdefinition[GO:0006309]  
1
  • PINC
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cell redox homeostasisdefinition[GO:0045454] silver  
1
  • InterPro 2 GO
Chromosome condensationdefinition[GO:0030261]  
1
  • UniProtKB
DNA catabolic processdefinition[GO:0006308]  
1
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • Ortholog Curator
Isoforms  Iso 1 and Iso 3   Mitochondrial respiratory chain complex I assemblydefinition[GO:0032981]  
1
  • UniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Isoform  Iso 3   Neuron differentiationdefinition[GO:0030182]  
1
  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Regulation of apoptotic DNA fragmentationdefinition[GO:1902510] silver  
1
  • Ortholog Compara
Enzymatic activity 
It requires the following cofactor
 FAD  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+9131  
Glutathione metabolism  hsa00480+51060  
 

Biophysicochemical properties

Kinetic parameters
KM 1.53 mM for NADH
KM 26 uM for cytochrome c

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AIFM1
GenomeRNAi: 9131
PRO: PR:O95831