CLDN1 - Claudin-1 - human protein (Function)
 
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Protein
Gene
References

 
CLDN1 »  Claudin-1
 
Protein also known as:  Senescence-associated epithelial membrane protein.
Gene name:  CLDN1
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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1 120 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cell-cell junction organizationdefinition[GO:0045216]  
1
  • IMPMGI
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+9076  
Hepatitis C  hsa05160+9076  
Leukocyte transendothelial migration  hsa04670+9076  
Pathogenic Escherichia coli infection  hsa05130+9076  
Tight junction  hsa04530+9076  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN1
GenomeRNAi: 9076
PRO: PR:O95832