CLDN1 - Claudin-1 - human protein (Function)
 
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Protein
Gene
References

 
CLDN1 »  Claudin-1
 
Protein also known as:  Senescence-associated epithelial membrane protein.
Gene name:  CLDN1
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.  
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  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cell-cell junction organizationdefinition[GO:0045216]  
1
  • IMPMGI
Establishment of skin barrierdefinition[GO:0061436]  
1
  • IMPUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+9076  
Hepatitis C  hsa05160+9076  
Leukocyte transendothelial migration  hsa04670+9076  
Pathogenic Escherichia coli infection  hsa05130+9076  
Tight junction  hsa04530+9076  
According to Reactome, this protein belongs to the following pathway:
Tight junction interactions  REACT_19373  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN1
GenomeRNAi: 9076
PRO: PR:O95832