LATS1 - Serine/threonine-protein kinase LATS1 - human protein (Function)
 
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LATS1 »  Serine/threonine-protein kinase LATS1   [ EC 2.7.11.1 ]
 
Protein also known as:  Large tumor suppressor homolog 1.
Gene name:  LATS1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 66 2
GENE REF ISO

Function

 show evidences
Overview 
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDABHF-UCL
  • IDAUniProtKB
GO biological process 
Cytoplasmic sequestering of proteindefinition[GO:0051220]  
1
  • IMPBHF-UCL
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IDAUniProtKB
Hippo signalingdefinition[GO:0035329]  
1
  • IDABHF-UCL
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
  • ISSOrtholog Curator
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IEAOrtholog Compara
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IMPBHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736]  
1
  • IDAUniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDABHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of actin filament polymerizationdefinition[GO:0030833]  
1
  • IDAUniProtKB
Regulation of protein complex assemblydefinition[GO:0043254]  
1
  • IMPBHF-UCL
Sister chromatid segregationdefinition[GO:0000819]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
2
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LATS1
GenomeRNAi: 9113
PRO: PR:O95835
Chemistry
GuidetoPHARMACOLOGY: 1515