NUDT14 - Uridine diphosphate glucose pyrophosphatase - human protein (Function)
 
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NUDT14 »  Uridine diphosphate glucose pyrophosphatase   [ EC 3.6.1.45 ]  (UGPPase)
 
Protein also known as:  Nucleoside diphosphate-linked moiety X motif 14 (Nudix motif 14).
Gene name:  NUDT14
Family name: Nudix hydrolase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.  
1
  • UniProtKB
GO molecular function 
ADP-ribose diphosphatase activitydefinition[GO:0047631] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
UDP-sugar diphosphatase activitydefinition[GO:0008768]  
1
  • EC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152]  
4
  • EC 2 GO
  • InterPro 2 GO
  • UniProtKB KW
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.45: UDP-sugar + H(2)O UMP + alpha-D-aldose 1-phosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH Optimum pH is 8.0-9.5.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 256281
PRO: PR:O95848