BPNT1 - 3'(2'),5'-bisphosphate nucleotidase 1 - human protein (Function)
 
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Protein
Gene
References

 
BPNT1 »  3'(2'),5'-bisphosphate nucleotidase 1   [ EC 3.1.3.7 ]
 
Protein also known as:  Bisphosphate 3'-nucleotidase 1.
Gene name:  BPNT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.  
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  • CuratedUniProtKB
GO molecular function 
3'(2'),5'-bisphosphate nucleotidase activitydefinition[GO:0008441]  
  • IEAEC 2 GO
Inositol-1,4-bisphosphate 1-phosphatase activitydefinition[GO:0004441] silver  
  • IEAOrtholog Compara
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAOrtholog Compara
GO biological process 
Dephosphorylationdefinition[GO:0016311]  
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  • TASGOC
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
1
  • TASPINC
Phosphatidylinositol phosphorylationdefinition[GO:0046854] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.7: Adenosine 3',5'-bisphosphate + H(2)O adenosine 5'-phosphate + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4-bisphosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+10380  
Sulfur metabolism  hsa00920+10380  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10380
PRO: PR:O95861