FADS2 - Fatty acid desaturase 2 - human protein (Function)
 
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FADS2 »  Fatty acid desaturase 2   [ EC 1.14.19.- ]
 
Protein also known as:  Delta(6) fatty acid desaturase (D6D).
Gene name:  FADS2
Family name: Fatty acid desaturase
Entry whose protein(s) existence is based on evidence at protein level
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1 69 3
GENE REF ISO

Function

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Overview 
Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.  
2
  • CuratedUniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Stearoyl-CoA 9-desaturase activitydefinition[GO:0004768] silver  
  • IEAOrtholog Compara
GO biological process 
Unsaturated fatty acid biosynthetic processdefinition[GO:0006636]  
  • IEAUniPathway
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
alpha-Linolenic acid metabolism  hsa00592+9415  
Biosynthesis of unsaturated fatty acids  hsa01040+9415  
PPAR signaling pathway  hsa03320+9415  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FADS2
GenomeRNAi: 9415
PRO: PR:O95864