BMP15 - Bone morphogenetic protein 15 - human protein (Function)
 
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BMP15 »  Bone morphogenetic protein 15  (BMP-15)
 
Protein also known as:  Growth/differentiation factor 9B (GDF-9B).
Gene name:  BMP15
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
GO biological process 
Female gamete generationdefinition[GO:0007292]  
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  • TASPINC
Granulosa cell developmentdefinition[GO:0060016] silver  
  • IEAInterPro 2 GO
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAInterPro 2 GO
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Note 
The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).  
  • CuratedUniProtKB
Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links