APC2 - Adenomatous polyposis coli protein 2 - human protein (Function)
 
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Protein
Gene
References

 
APC2 »  Adenomatous polyposis coli protein 2
 
Protein also known as:  Adenomatous polyposis coli protein-like (APC-like).
Gene name:  APC2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.  
3
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IDAMGI
Microtubule bindingdefinition[GO:0008017] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
  • IPIIntAct
GO biological process 
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
2
  • IDABHF-UCL
Negative regulation of catenin import into nucleusdefinition[GO:0035414]  
1
  • IDABHF-UCL
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+10297  
Colorectal cancer  hsa05210+10297  
Endometrial cancer  hsa05213+10297  
HTLV-I infection  hsa05166+10297  
Pathways in cancer  hsa05200+10297  
Regulation of actin cytoskeleton  hsa04810+10297  
Wnt signaling pathway  hsa04310+10297  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10297
PRO: PR:O95996