BCL10 - B-cell lymphoma/leukemia 10 - human protein (Function)
 
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Protein
Gene
References

 
BCL10 »  B-cell lymphoma/leukemia 10
 
Protein also known as:  CED-3/ICH-1 prodomain homologous E10-like regulator (CIPER).
Gene name:  BCL10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 117 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in adaptive immune response (PubMed25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed18264101).  
3
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Contributes to kinase activator activitydefinition[GO:0019209]  
1
  • UniProtKB
Kinase bindingdefinition[GO:0019900]  
2
  • UniProtKB
NF-kappaB bindingdefinition[GO:0051059]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein kinase B bindingdefinition[GO:0043422]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Protein self-associationdefinition[GO:0043621]  
1
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Adaptive immune responsedefinition[GO:0002250]  
2
  • UniProtKB
B cell apoptotic processdefinition[GO:0001783] silver  
1
  • Ortholog Compara
Cell deathdefinition[GO:0008219]  
1
  • UniProtKB
Cellular defense responsedefinition[GO:0006968] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Immunoglobulin mediated immune responsedefinition[GO:0016064] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB
Interleukin-6 biosynthetic processdefinition[GO:0042226]  
1
  • UniProtKB
Lymphotoxin A biosynthetic processdefinition[GO:0042109]  
1
  • UniProtKB
Negative regulation of mature B cell apoptotic processdefinition[GO:0002906]  
1
  • UniProtKB
Neural tube closuredefinition[GO:0001843]  
1
  • UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043280] silver  
1
  • Ortholog Compara
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Positive regulation of interleukin-8 biosynthetic processdefinition[GO:0045416]  
1
  • UniProtKB
Positive regulation of mast cell cytokine productiondefinition[GO:0032765]  
1
  • UniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
2
  • UniProtKB
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • UniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • UniProtKB
Positive regulation of T cell activationdefinition[GO:0050870] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
2
  • UniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • UniProtKB
Regulation of T cell receptor signaling pathwaydefinition[GO:0050856] silver  
1
  • Ortholog Compara
Response to fooddefinition[GO:0032094]  
1
  • UniProtKB
Response to fungusdefinition[GO:0009620] silver  
1
  • Ortholog Compara
Response to molecule of bacterial origindefinition[GO:0002237]  
1
  • UniProtKB
T cell apoptotic processdefinition[GO:0070231] silver  
1
  • Ortholog Compara
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • UniProtKB
Toll-like receptor signaling pathwaydefinition[GO:0002224]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+8915  
T cell receptor signaling pathway  hsa04660+8915  
Tuberculosis  hsa05152+8915  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  REACT_118656  
Downstream TCR signaling  REACT_12555  
FCERI mediated NF-kB activation  REACT_163994  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL10
GenomeRNAi: 8915
PRO: PR:O95999