HAND1 - Heart- and neural crest derivatives-expressed protein 1 - human protein (Function)
 
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HAND1 »  Heart- and neural crest derivatives-expressed protein 1
 
Protein also known as:  Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND).
Gene name:  HAND1
Entry whose protein(s) existence is based on evidence at transcript level
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1 20 1
GENE REF ISO

Function

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Overview 
Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
1
  • IPIBHF-UCL
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Contributes to protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • NASBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Blastocyst developmentdefinition[GO:0001824]  
1
  • IEPBHF-UCL
Cardiac left ventricle formationdefinition[GO:0003218]  
1
  • IMPBHF-UCL
Cardiac right ventricle formationdefinition[GO:0003219]  
1
  • IMPBHF-UCL
Cardiac septum morphogenesisdefinition[GO:0060411]  
1
  • IMPBHF-UCL
Cartilage morphogenesisdefinition[GO:0060536] silver  
  • IEAOrtholog Compara
Embryonic heart tube developmentdefinition[GO:0035050]  
  • ISSOrtholog Curator
Embryonic heart tube formationdefinition[GO:0003144] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Mesenchyme developmentdefinition[GO:0060485] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDABHF-UCL
Trophectodermal cell differentiationdefinition[GO:0001829]  
1
  • IEPBHF-UCL
Trophoblast giant cell differentiationdefinition[GO:0060707] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • IMPBHF-UCL
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAND1
GenomeRNAi: 9421
PRO: PR:O96004