PAK4 - Serine/threonine-protein kinase PAK 4 - human protein (Function)
 
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PAK4 »  Serine/threonine-protein kinase PAK 4   [ EC 2.7.11.1 ]
 
Protein also known as:  p21-activated kinase 4 (PAK-4).
Gene name:  PAK4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • NASPINC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IBARefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cell growthdefinition[GO:0016049]  
1
  • TASUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • TASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASUniProtKB
Not  Mitotic cell cycledefinition[GO:0000278] silver  
  • IBARefGenome
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+10298  
ErbB signaling pathway  hsa04012+10298  
Focal adhesion  hsa04510+10298  
Regulation of actin cytoskeleton  hsa04810+10298  
Renal cell carcinoma  hsa05211+10298  
T cell receptor signaling pathway  hsa04660+10298  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PAK4
GenomeRNAi: 10298
PRO: PR:O96013
Chemistry
GuidetoPHARMACOLOGY: 2136