WNT11 - Protein Wnt-11 - human protein (Function)
 
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WNT11 »  Protein Wnt-11
 
Gene name:  WNT11
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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1 35 1
GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.  
  • CuratedUniProtKB
GO molecular function 
Frizzled bindingdefinition[GO:0005109] silver  
  • IBARefGenome
Protein kinase activator activitydefinition[GO:0030295]  
2
  • IMPUniProtKB
Ras GTPase activator activitydefinition[GO:0005099]  
1
  • IMPUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Adrenal gland developmentdefinition[GO:0030325]  
1
  • IEPUniProtKB
Artery morphogenesisdefinition[GO:0048844] silver  
  • IEAOrtholog Compara
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cell fate commitmentdefinition[GO:0045165] silver  
  • IBARefGenome
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
Cloacal septationdefinition[GO:0060197]  
1
  • IEPUniProtKB
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • IEPUniProtKB
Lung-associated mesenchyme developmentdefinition[GO:0060484]  
1
  • IEPUniProtKB
Mesonephric duct developmentdefinition[GO:0072177]  
1
  • IEPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IMPUniProtKB
Negative regulation of cartilage developmentdefinition[GO:0061037]  
1
  • NASUniProtKB
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IMPUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Negative regulation of fibroblast growth factor productiondefinition[GO:0090272] silver  
  • IEAOrtholog Compara
Negative regulation of mesenchymal cell proliferationdefinition[GO:0072201] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IMPUniProtKB
Neuroendocrine cell differentiationdefinition[GO:0061101]  
1
  • IMPUniProtKB
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
  • IBARefGenome
Non-canonical Wnt signaling pathwaydefinition[GO:0035567] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
1
  • IMPBHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPUniProtKB
Positive regulation of protein kinase activitydefinition[GO:0045860]  
2
  • IMPGOC
Positive regulation of protein kinase C signalingdefinition[GO:0090037]  
1
  • IMPUniProtKB
Positive regulation of Ras GTPase activitydefinition[GO:0032320]  
1
  • IMPUniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • IMPUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Positive regulation of transforming growth factor beta2 productiondefinition[GO:0032915] silver  
  • IEAOrtholog Compara
Protein localization to cell surfacedefinition[GO:0034394]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IMPUniProtKB
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Tight junction assemblydefinition[GO:0070830] silver  
  • IEAOrtholog Compara
Ureteric bud morphogenesisdefinition[GO:0060675]  
1
  • IEPUniProtKB
Ventricular septum morphogenesisdefinition[GO:0060412] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Ca2+ pathway  REACT_172761  
Class B/2 (Secretin family receptors)  REACT_18372  
PCP/CE pathway  REACT_172581  
WNT ligand biogenesis and trafficking  REACT_163710  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT11
GenomeRNAi: 7481
PRO: PR:O96014