MT-CYB - Cytochrome b - human protein (Function)
 
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MT-CYB »  Cytochrome b
 
Protein also known as:  Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
Gene name:  MT-CYB
Family name: Cytochrome b
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 1
GENE REF ISO

Function

 show evidences
Overview 
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.  
1
  • UniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Ubiquinol-cytochrome-c reductase activitydefinition[GO:0008121]  
1
  • UniProtKB
GO biological process 
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
2
  • GOC
  • InterPro 2 GO
Hyperosmotic salinity responsedefinition[GO:0042538] silver  
1
  • Ortholog Compara
Mitochondrial electron transport, ubiquinol to cytochrome cdefinition[GO:0006122]  
1
  • UniProtKB
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Response to cadmium iondefinition[GO:0046686] silver  
1
  • Ortholog Compara
Response to calcium iondefinition[GO:0051592] silver  
1
  • Ortholog Compara
Response to cobalamindefinition[GO:0033590] silver  
1
  • Ortholog Compara
Response to copper iondefinition[GO:0046688] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to glucagondefinition[GO:0033762] silver  
1
  • Ortholog Compara
Response to heatdefinition[GO:0009408] silver  
1
  • Ortholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to mercury iondefinition[GO:0046689] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Enzymatic activity 
It requires the following cofactor
 heme : Binds 2 heme groups non-covalently.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4519  
Cardiac muscle contraction  hsa04260+4519  
Huntington's disease  hsa05016+4519  
Metabolic pathways  hsa01100+4519  
Oxidative phosphorylation  hsa00190+4519  
Parkinson's disease  hsa05012+4519  
According to Reactome, this protein belongs to the following pathway:
Respiratory electron transport  R-HSA-611105  
Note 
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.  
1
  • UniProtKB
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MT-CYB
GenomeRNAi: 4519
PRO: PR:P00156