MT-CYB - Cytochrome b - human protein (Function)
 
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MT-CYB »  Cytochrome b
 
Protein also known as:  Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
Gene name:  MT-CYB
Family name: Cytochrome b
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 1
GENE REF ISO

Function

 show evidences
Overview 
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Ubiquinol-cytochrome-c reductase activitydefinition[GO:0008121]  
1
  • NASUniProtKB
GO biological process 
Cation transportdefinition[GO:0006812]  
1
  • NASGOC
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
1
  • NASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • NASGOC
Mitochondrial electron transport, ubiquinol to cytochrome cdefinition[GO:0006122]  
1
  • NASUniProtKB
Monovalent inorganic cation transportdefinition[GO:0015672]  
1
  • NASGOC
Transmembrane transportdefinition[GO:0055085]  
1
  • NASGOC
Transportdefinition[GO:0006810]  
1
  • NASGOC
Enzymatic activity 
It requires the following cofactor
Binds 2 heme groups non-covalently (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4519  
Cardiac muscle contraction  hsa04260+4519  
Huntington's disease  hsa05016+4519  
Metabolic pathways  hsa01100+4519  
Oxidative phosphorylation  hsa00190+4519  
Parkinson's disease  hsa05012+4519  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Note 
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MT-CYB
PRO: PR:P00156