ADH1B - Alcohol dehydrogenase 1B - human protein (Function)
 
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ADH1B »  Alcohol dehydrogenase 1B   [ EC 1.1.1.1 ]
 
Protein also known as:  Alcohol dehydrogenase subunit beta.
Gene name:  ADH1B
Entry whose protein(s) existence is based on evidence at protein level
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1 113 1
GENE REF ISO

Function

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GO molecular function 
Alcohol dehydrogenase activity, zinc-dependentdefinition[GO:0004024]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Ethanol oxidationdefinition[GO:0006069]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.1: An alcohol + NAD(+) an aldehyde or ketone + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+125  
Fatty acid metabolism  hsa00071+125  
Glycolysis / Gluconeogenesis  hsa00010+125  
Metabolic pathways  hsa01100+125  
Metabolism of xenobiotics by cytochrome P450  hsa00980+125  
Retinol metabolism  hsa00830+125  
Tyrosine metabolism  hsa00350+125  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00325
Other
GeneWiki: ADH1B
GenomeRNAi: 125
PRO: PR:P00325