ADH1C - Alcohol dehydrogenase 1C - human protein (Function)
 
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Protein
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ADH1C »  Alcohol dehydrogenase 1C   [ EC 1.1.1.1 ]
 
Protein also known as:  Alcohol dehydrogenase subunit gamma.
Gene name:  ADH1C
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 1
GENE REF ISO

Function

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GO molecular function 
Alcohol dehydrogenase (NAD) activitydefinition[GO:0004022]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Ethanol oxidationdefinition[GO:0006069]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.1: An alcohol + NAD(+) an aldehyde or ketone + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+126  
Fatty acid metabolism  hsa00071+126  
Glycolysis / Gluconeogenesis  hsa00010+126  
Metabolic pathways  hsa01100+126  
Metabolism of xenobiotics by cytochrome P450  hsa00980+126  
Retinol metabolism  hsa00830+126  
Tyrosine metabolism  hsa00350+126  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Note 
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.  
  • CuratedUniProtKB
Caution 
The reference genome assembly, GRCh37, describes a non-functional copy of that gene with a stop codon at position 78. However, this premature stop codon is not present in available mRNAs.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00326
Other
GeneWiki: ADH1C
GenomeRNAi: 126
PRO: PR:P00326