LDHA - L-lactate dehydrogenase A chain - human protein (Function)
 
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LDHA »  L-lactate dehydrogenase A chain   [ EC 1.1.1.27 ]  (LDH-A)
 
Protein also known as:  Cell proliferation-inducing gene 19 protein.
Gene name:  LDHA
Family name: LDH/MDH » LDH
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
L-lactate dehydrogenase activitydefinition[GO:0004459]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
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  • Ortholog Compara
Glycolytic processdefinition[GO:0006096]  
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  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
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  • UniProtKB KW
Isoform  Iso 3   Substantia nigra developmentdefinition[GO:0021762]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.27: (S)-lactate + NAD(+) pyruvate + NADH.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+3939  
Glycolysis / Gluconeogenesis  hsa00010+3939  
Metabolic pathways  hsa01100+3939  
Propanoate metabolism  hsa00640+3939  
Pyruvate metabolism  hsa00620+3939  
According to Reactome, this protein belongs to the following pathway:
Pyruvate metabolism  REACT_2071  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00338
Other
GeneWiki: LDHA
GenomeRNAi: 3939
PRO: PR:P00338