LDHA - L-lactate dehydrogenase A chain - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
LDHA »  L-lactate dehydrogenase A chain   [ EC 1.1.1.27 ]  (LDH-A)
 
Protein also known as:  Cell proliferation-inducing gene 19 protein.
Gene name:  LDHA
Family name: LDH/MDH » LDH
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 134 5
GENE REF ISO

Function

 show evidences
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Kinase bindingdefinition[GO:0019900] silver  
1
  • Ortholog Compara
L-lactate dehydrogenase activitydefinition[GO:0004459]  
1
  • UniProtKB
NAD bindingdefinition[GO:0051287] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
1
  • Ortholog Compara
Glycolytic processdefinition[GO:0006096]  
1
  • UniProtKB
Lactate metabolic processdefinition[GO:0006089] silver  
1
  • Ortholog Compara
NAD metabolic processdefinition[GO:0019674] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Post-embryonic organ developmentdefinition[GO:0048569] silver  
1
  • Ortholog Compara
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Isoform  Iso 3   Substantia nigra developmentdefinition[GO:0021762]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.27: (S)-lactate + NAD(+) pyruvate + NADH.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+3939  
Glycolysis / Gluconeogenesis  hsa00010+3939  
Metabolic pathways  hsa01100+3939  
Propanoate metabolism  hsa00640+3939  
Pyruvate metabolism  hsa00620+3939  
According to Reactome, this protein belongs to the following pathway:
Pyruvate metabolism  R-HSA-70268  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00338
Other
GeneWiki: LDHA
GenomeRNAi: 3939
PRO: PR:P00338