ALDH1A1 - Retinal dehydrogenase 1 - human protein (Function)
 
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ALDH1A1 »  Retinal dehydrogenase 1   [ EC 1.2.1.36 ]  (RalDH1)
 
Protein also known as:  Aldehyde dehydrogenase family 1 member A1.
Gene name:  ALDH1A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 143 1
GENE REF ISO

Function

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Overview 
Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Androgen bindingdefinition[GO:0005497]  
1
  • TASPINC
Ras GTPase activator activitydefinition[GO:0005099]  
1
  • TASUniProtKB
Retinal dehydrogenase activitydefinition[GO:0001758]  
  • IEAEC 2 GO
GO biological process 
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • TASPINC
Positive regulation of Ras GTPase activitydefinition[GO:0032320]  
1
  • TASGOC
Retinol metabolic processdefinition[GO:0042572]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.36: Retinal + NAD(+) + H(2)O retinoate + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+216  
Retinol metabolism  hsa00830+216  
According to Reactome, this protein belongs to the following pathway:
Ethanol oxidation  REACT_34  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00352
Other
GeneWiki: ALDH1A1
GenomeRNAi: 216
PRO: PR:P00352