ALDH1A1 » Retinal dehydrogenase 1 (RalDH1)

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Protein also known as: Aldehyde dehydrogenase family 1 member A1.

Gene name: ALDH1A1

Family name: Aldehyde dehydrogenase

This protein has been shown to exist at protein level

Protein

Recommended name: Retinal dehydrogenase 1 Short: RALDH 1 , RalDH1
Alternative names: ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic

Gene

Recommended name: ALDH1A1
Alternative names: ALDC; ALDH1; PUMB1

Family

Family: Aldehyde dehydrogenase

History

neXtProt: Integrated 2010-03-01; Last updated 2013-02-18
UniProtKB: Integrated 1986-07-21; Updated 2013-02-06; Entry version 142; Last sequence update 2007-01-23; Sequence version 2; Complete UniProtKB history

This protein has been shown to exist at protein level

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1 88 1

GENE REF ISO

Function

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Overview

Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

CuratedUniProtKB

GO molecular function

Androgen bindingdefinition[GO:0005497]

Interacting selectively and non-covalently with any androgen, male sex hormones.

Evidence 1: Traceable Author Statement PINC

The 56 kDa androgen binding protein is an aldehyde dehydrogenase.

Pereira F., Rosenmann E., Nylen E., Kaufman M., Pinsky L., Wrogemann K.

Biochem. Biophys. Res. Commun. 175, 831-838 (1991) [PubMed:1709013]

We have described a 56 kDa protein from genital skin fibroblasts that specifically binds androgen and that is generally not expressed in genital skin fibroblasts from patients with androgen insensitivity due to genetic defects of the androgen receptor. We have isolated a partial cDNA clone for the 56 kDa protein from an expression library of genital skin fibroblasts. In vitro translation of message selected with this clone faithfully produces the 56 kDa protein which can be immuneprecipitated with an anti-56 kDa antiserum. Northern blots probed with this clone show a 2.2 kb message, which parallels the expression of the 56 kDa protein. The sequence of this 998bp clone is identical to human liver aldehyde dehydrogenase 1, the cytoplasmic isoenzyme. On activity gels of genital skin fibroblast cytosol covalently labelled with androgen, aldehyde dehydrogenase activity comigrates with the single band labelled specifically with androgen. Thus, the 56 kDa androgen binding protein is an aldehyde dehydrogenase, which is prominently expressed in normal genital skin fibroblasts, but not in non-genital skin fibroblasts.

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TASPINC

Ras GTPase activator activitydefinition[GO:0005099]

Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily.

Evidence 1: Traceable Author Statement UniProtKB

The 56 kDa androgen binding protein is an aldehyde dehydrogenase.

Pereira F., Rosenmann E., Nylen E., Kaufman M., Pinsky L., Wrogemann K.

Biochem. Biophys. Res. Commun. 175, 831-838 (1991) [PubMed:1709013]

We have described a 56 kDa protein from genital skin fibroblasts that specifically binds androgen and that is generally not expressed in genital skin fibroblasts from patients with androgen insensitivity due to genetic defects of the androgen receptor. We have isolated a partial cDNA clone for the 56 kDa protein from an expression library of genital skin fibroblasts. In vitro translation of message selected with this clone faithfully produces the 56 kDa protein which can be immuneprecipitated with an anti-56 kDa antiserum. Northern blots probed with this clone show a 2.2 kb message, which parallels the expression of the 56 kDa protein. The sequence of this 998bp clone is identical to human liver aldehyde dehydrogenase 1, the cytoplasmic isoenzyme. On activity gels of genital skin fibroblast cytosol covalently labelled with androgen, aldehyde dehydrogenase activity comigrates with the single band labelled specifically with androgen. Thus, the 56 kDa androgen binding protein is an aldehyde dehydrogenase, which is prominently expressed in normal genital skin fibroblasts, but not in non-genital skin fibroblasts.

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TASUniProtKB

Retinal dehydrogenase activitydefinition[GO:0001758]

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

IEAEC 2 GO

GO biological process

Cellular aldehyde metabolic processdefinition[GO:0006081]

The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.

Evidence 1: Traceable Author Statement PINC

The 56 kDa androgen binding protein is an aldehyde dehydrogenase.

Pereira F., Rosenmann E., Nylen E., Kaufman M., Pinsky L., Wrogemann K.

Biochem. Biophys. Res. Commun. 175, 831-838 (1991) [PubMed:1709013]

We have described a 56 kDa protein from genital skin fibroblasts that specifically binds androgen and that is generally not expressed in genital skin fibroblasts from patients with androgen insensitivity due to genetic defects of the androgen receptor. We have isolated a partial cDNA clone for the 56 kDa protein from an expression library of genital skin fibroblasts. In vitro translation of message selected with this clone faithfully produces the 56 kDa protein which can be immuneprecipitated with an anti-56 kDa antiserum. Northern blots probed with this clone show a 2.2 kb message, which parallels the expression of the 56 kDa protein. The sequence of this 998bp clone is identical to human liver aldehyde dehydrogenase 1, the cytoplasmic isoenzyme. On activity gels of genital skin fibroblast cytosol covalently labelled with androgen, aldehyde dehydrogenase activity comigrates with the single band labelled specifically with androgen. Thus, the 56 kDa androgen binding protein is an aldehyde dehydrogenase, which is prominently expressed in normal genital skin fibroblasts, but not in non-genital skin fibroblasts.

ref

show all

TASPINC

Positive regulation of Ras GTPase activitydefinition[GO:0032320]

Any process that activates or increases the activity of a GTPase of the Ras superfamily.

Evidence 1: Traceable Author Statement GOC

The 56 kDa androgen binding protein is an aldehyde dehydrogenase.

Pereira F., Rosenmann E., Nylen E., Kaufman M., Pinsky L., Wrogemann K.

Biochem. Biophys. Res. Commun. 175, 831-838 (1991) [PubMed:1709013]

We have described a 56 kDa protein from genital skin fibroblasts that specifically binds androgen and that is generally not expressed in genital skin fibroblasts from patients with androgen insensitivity due to genetic defects of the androgen receptor. We have isolated a partial cDNA clone for the 56 kDa protein from an expression library of genital skin fibroblasts. In vitro translation of message selected with this clone faithfully produces the 56 kDa protein which can be immuneprecipitated with an anti-56 kDa antiserum. Northern blots probed with this clone show a 2.2 kb message, which parallels the expression of the 56 kDa protein. The sequence of this 998bp clone is identical to human liver aldehyde dehydrogenase 1, the cytoplasmic isoenzyme. On activity gels of genital skin fibroblast cytosol covalently labelled with androgen, aldehyde dehydrogenase activity comigrates with the single band labelled specifically with androgen. Thus, the 56 kDa androgen binding protein is an aldehyde dehydrogenase, which is prominently expressed in normal genital skin fibroblasts, but not in non-genital skin fibroblasts.

ref

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TASGOC

Retinol metabolic processdefinition[GO:0042572]

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.

IEAUniPathway

Enzymatic activity

This protein acts as an enzyme. It is known to catalyze the following reaction

EC 1.2.1.36: Retinal + NAD(+) + H(2)O ⇄ retinoate + NADH.

CuratedUniProtKB

Pathways

This protein is involved in the following pathway

Cofactor metabolism; retinol metabolism

CuratedUniProtKB

According to KEGG, this protein belongs to the following pathways:

Metabolic pathways hsa01100+216

Retinol metabolism hsa00830+216

According to Reactome, this protein belongs to the following pathway:

Metabolism REACT_111217

More information is available from:

BioCyc: MetaCyc:HS09183-MONOMER

Keywords

Molecular function

Oxidoreductase definition [KW-0560]

Enzyme that catalyzes the oxidation of one compound with the reduction of another.

Technical term

Reference proteome definition [KW-1185]

A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.

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Function

Keywords

neXtProt