GLUD1 - Glutamate dehydrogenase 1, mitochondrial - human protein (Function)
 
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GLUD1 »  Glutamate dehydrogenase 1, mitochondrial
 
Gene name:  GLUD1
Entry whose protein(s) existence is based on evidence at protein level
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1 79 1
GENE REF ISO

Function

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Overview 
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531]  
1
  • IDABHF-UCL
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Glutamate dehydrogenase (NAD+) activitydefinition[GO:0004352]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Glutamate dehydrogenase [NAD(P)+] activitydefinition[GO:0004353]  
1
  • IDABHF-UCL
GTP bindingdefinition[GO:0005525]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • TASBHF-UCL
Leucine bindingdefinition[GO:0070728]  
1
  • IDABHF-UCL
NAD+ bindingdefinition[GO:0070403]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Glutamate biosynthetic processdefinition[GO:0006537]  
1
  • IDABHF-UCL
Glutamate catabolic processdefinition[GO:0006538]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Glutamine metabolic processdefinition[GO:0006541]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Positive regulation of insulin secretiondefinition[GO:0032024]  
1
  • IMPBHF-UCL
Tricarboxylic acid metabolic processdefinition[GO:0072350]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.1.3: L-glutamate + H(2)O + NAD(P)(+) 2-oxoglutarate + NH(3) + NAD(P)H.  
  • CuratedUniProtKB
It is regulated in the following manner
Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+2746  
Arginine and proline metabolism  hsa00330+2746  
D-Glutamine and D-glutamate metabolism  hsa00471+2746  
Metabolic pathways  hsa01100+2746  
Nitrogen metabolism  hsa00910+2746  
Proximal tubule bicarbonate reclamation  hsa04964+2746  
According to Reactome, this protein belongs to the following pathway:
Amino acid synthesis and interconversion (transamination)  REACT_238  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00367
Other
GeneWiki: Glutamate_dehydrogenase_1
GenomeRNAi: 2746
PRO: PR:P00367