CYB5R3 - NADH-cytochrome b5 reductase 3 - human protein (Function)
 
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CYB5R3 »  NADH-cytochrome b5 reductase 3   [ EC 1.6.2.2 ]  (B5R)
 
Protein also known as:  Diaphorase-1. Cleaved into:  NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form.
Gene name:  CYB5R3
Entry whose protein(s) existence is based on evidence at protein level
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1 62 3
GENE REF ISO

Function

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Overview 
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.  
  • CuratedUniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531] silver  
  • IEAOrtholog Compara
AMP bindingdefinition[GO:0016208] silver  
  • IEAOrtholog Compara
Isoform  Iso 2   FAD bindingdefinition[GO:0071949]  
1
  • IDAUniProtKB
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAOrtholog Compara
NAD bindingdefinition[GO:0051287] silver  
  • IEAOrtholog Compara
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Cholesterol biosynthetic processdefinition[GO:0006695]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.2.2: NADH + 2 ferricytochrome b5 NAD(+) + H(+) + 2 ferrocytochrome b5.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+1727  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00387
Other
GeneWiki: CYB5R3
GenomeRNAi: 1727
PRO: PR:P00387