GSR - Glutathione reductase, mitochondrial - human protein (Function)
 
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GSR »  Glutathione reductase, mitochondrial   [ EC 1.8.1.7 ]  (GR)
 
Gene name:  GSR
Entry whose protein(s) existence is based on evidence at protein level
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1 63 5
GENE REF ISO

Function

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Overview 
Maintains high levels of reduced glutathione in the cytosol.  
  • CuratedUniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
NADP bindingdefinition[GO:0050661] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Glutathione metabolic processdefinition[GO:0006749] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.8.1.7: 2 glutathione + NADP(+) glutathione disulfide + NADPH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 FAD per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glutathione metabolism  hsa00480+2936  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
The active site is a redox-active disulfide bond.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00390
Other
GeneWiki: Glutathione_reductase
GenomeRNAi: 2936
PRO: PR:P00390
Chemistry
GuidetoPHARMACOLOGY: 2613