MT-CO1 - Cytochrome c oxidase subunit 1 - human protein (Function)
 
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MT-CO1 »  Cytochrome c oxidase subunit 1   [ EC 1.9.3.1 ]
 
Protein also known as:  Cytochrome c oxidase polypeptide I.
Gene name:  MT-CO1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 1
GENE REF ISO

Function

 show evidences
Overview 
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the proton-translocating cytochrome oxidase (cox) superfamily  3.D.4.11.1  
GO molecular function 
Contributes to cytochrome-c oxidase activitydefinition[GO:0004129]  
1
  • IMPUniProtKB
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIHGNC
GO biological process 
Aerobic respirationdefinition[GO:0009060] silver  
  • IEAInterPro 2 GO
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
1
  • IMPGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Oxidative phosphorylationdefinition[GO:0006119]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.9.3.1: 4 ferrocytochrome c + O(2) + 4 H(+) 4 ferricytochrome c + 2 H(2)O.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4512  
Cardiac muscle contraction  hsa04260+4512  
Huntington's disease  hsa05016+4512  
Metabolic pathways  hsa01100+4512  
Oxidative phosphorylation  hsa00190+4512  
Parkinson's disease  hsa05012+4512  
According to Reactome, this protein belongs to the following pathway:
Respiratory electron transport  REACT_22393  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MT-CO1
GenomeRNAi: 4512
PRO: PR:P00395