CP - Ceruloplasmin - human protein (Function)
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CP »  Ceruloplasmin   [ EC ]
Protein also known as:  Ferroxidase.
Gene name:  CP
Family name: Multicopper oxidase
Entry whose protein(s) existence is based on evidence at protein level
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Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
Copper ion bindingdefinition[GO:0005507] silver  
  • IEAOrtholog Compara
Ferroxidase activitydefinition[GO:0004322]  
  • IEAEC 2 GO
GO biological process 
Copper ion transportdefinition[GO:0006825]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4 Fe(2+) + 4 H(+) + O(2) 4 Fe(3+) + 2 H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 6 copper ions per monomer.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathway:
Porphyrin and chlorophyll metabolism  hsa00860+1356  
According to Reactome, this protein belongs to the following pathways:
Iron uptake and transport  REACT_25060  
Metal ion SLC transporters  REACT_20547  
More information is available from:


Biological process 
Copper transport  definition   [KW-0187]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P00450
GeneWiki: Ceruloplasmin
GenomeRNAi: 1356
PRO: PR:P00450