F8 - Coagulation factor VIII - human protein (Function)
 
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F8 »  Coagulation factor VIII
 
Protein also known as:  Procoagulant component. Cleaved into:  Factor VIII B chain; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIIIa light chain.
Gene name:  F8
Family name: Multicopper oxidase
Entry whose protein(s) existence is based on evidence at protein level
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1 448 2
GENE REF ISO

Function

 show evidences
Overview 
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.  
1
  • UniProtKB
GO molecular function 
Copper ion bindingdefinition[GO:0005507] silver  
1
  • InterPro 2 GO
Oxidoreductase activitydefinition[GO:0016491] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
1
  • Ortholog Compara
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • UniProtKB KW
Cell adhesiondefinition[GO:0007155] silver  
1
  • InterPro 2 GO
Oxidation-reduction processdefinition[GO:0055114] silver  
1
  • InterPro 2 GO
Proteolysisdefinition[GO:0006508] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2157  
According to Reactome, this protein belongs to the following pathway:
Intrinsic Pathway  REACT_326  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Factor_VIII
GenomeRNAi: 2157
PRO: PR:P00451
Chemistry
GuidetoPHARMACOLOGY: 2607