F13A1 - Coagulation factor XIII A chain - human protein (Function)
 
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F13A1 »  Coagulation factor XIII A chain   [ EC 2.3.2.13 ]  (Coagulation factor XIIIa)
 
Protein also known as:  Protein-glutamine gamma-glutamyltransferase A chain.
Gene name:  F13A1
Entry whose protein(s) existence is based on evidence at protein level
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1 137 1
GENE REF ISO

Function

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Overview 
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Peptide cross-linkingdefinition[GO:0018149] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.2.13: Protein glutamine + alkylamine protein N(5)-alkylglutamine + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2162  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links