PNP - Purine nucleoside phosphorylase - human protein (Function)
 
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PNP »  Purine nucleoside phosphorylase   [ EC 2.4.2.1 ]  (PNP)
 
Protein also known as:  Inosine-guanosine phosphorylase.
Gene name:  PNP
Family name: PNP/MTAP phosphorylase
Entry whose protein(s) existence is based on evidence at protein level
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1 67 1
GENE REF ISO

Function

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Overview 
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.  
1
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144]  
1
  • IDAUniProtKB
Nucleoside bindingdefinition[GO:0001882]  
1
  • IDAUniProtKB
Phosphate ion bindingdefinition[GO:0042301]  
1
  • IDAUniProtKB
Purine nucleobase bindingdefinition[GO:0002060]  
1
  • IDAUniProtKB
Purine-nucleoside phosphorylase activitydefinition[GO:0004731]  
5
  • IDAUniProtKB
  • IDAMGI
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • IMPUniProtKB
Inosine catabolic processdefinition[GO:0006148]  
1
  • IDAMGI
Interleukin-2 secretiondefinition[GO:0070970]  
1
  • IMPUniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwaydefinition[GO:0034356]  
1
  • IGIUniProtKB
Nicotinamide riboside catabolic processdefinition[GO:0006738]  
1
  • IDAUniProtKB
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
1
  • IDAUniProtKB
Positive regulation of alpha-beta T cell differentiationdefinition[GO:0046638]  
1
  • IDAMGI
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDAMGI
Response to drugdefinition[GO:0042493]  
2
  • IDAUniProtKB
Urate biosynthetic processdefinition[GO:0034418]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.1: Purine nucleoside + phosphate purine + alpha-D-ribose 1-phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+4860  
Nicotinate and nicotinamide metabolism  hsa00760+4860  
Purine metabolism  hsa00230+4860  
Pyrimidine metabolism  hsa00240+4860  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00491
Other
GeneWiki: Purine_nucleoside_phosphorylase
GenomeRNAi: 4860
PRO: PR:P00491