EGFR - Epidermal growth factor receptor - human protein (Function)
 
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EGFR »  Epidermal growth factor receptor   [ EC 2.7.10.1 ]
 
Protein also known as:  Receptor tyrosine-protein kinase erbB-1.
Gene name:  EGFR
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.  
1
  • UniProtKB
Isoform  Iso 2   May act as an antagonist of EGF action.  
1
  • UniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • UniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Epidermal growth factor bindingdefinition[GO:0048408] silver  
1
  • Ortholog Compara
Epidermal growth factor-activated receptor activitydefinition[GO:0005006]  
4
  • UniProtKB
Glycoprotein bindingdefinition[GO:0001948] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802]  
13
  • IntAct
Integrin bindingdefinition[GO:0005178] silver  
1
  • Ortholog Compara
MAP kinase kinase kinase activitydefinition[GO:0004709]  
1
  • UniProtKB
Contributes to nitric-oxide synthase regulator activitydefinition[GO:0030235]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
97
  • IntAct
  • UniProtKB
  • HGNC
  • WormBase
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
4
  • UniProtKB
Receptor signaling protein tyrosine kinase activitydefinition[GO:0004716] silver  
1
  • InterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • MGI
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186] silver  
1
  • Ortholog Compara
Activation of phospholipase A2 activity by calcium-mediated signalingdefinition[GO:0043006]  
1
  • UniProtKB
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • UniProtKB
Alkanesulfonate metabolic processdefinition[GO:0019694] silver  
1
  • Ortholog Compara
Astrocyte activationdefinition[GO:0048143] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • MGI
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
1
  • Ortholog Curator
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • UniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
1
  • Ortholog Compara
Cerebral cortex cell migrationdefinition[GO:0021795] silver  
1
  • Ortholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
1
  • Ortholog Compara
Diterpenoid metabolic processdefinition[GO:0016101] silver  
1
  • Ortholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
2
  • UniProtKB
  • MGI
Hair follicle developmentdefinition[GO:0001942] silver  
1
  • Ortholog Compara
Hydrogen peroxide metabolic processdefinition[GO:0042743] silver  
1
  • Ortholog Compara
Learning or memorydefinition[GO:0007611]  
1
  • Ortholog Curator
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Magnesium ion homeostasisdefinition[GO:0010960] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • GOC
Morphogenesis of an epithelial folddefinition[GO:0060571] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of mitotic cell cycledefinition[GO:0045930] silver  
1
  • Ortholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • UniProtKB
Ossificationdefinition[GO:0001503]  
1
  • UniProtKB
Ovulation cycledefinition[GO:0042698] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
7
  • GOC
  • InterPro 2 GO
  • EC 2 GO
  • UniProtKB KW
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • MGI
Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycledefinition[GO:0031659]