EGFR - Epidermal growth factor receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
EGFR »  Epidermal growth factor receptor   [ EC 2.7.10.1 ]
 
Protein also known as:  Receptor tyrosine-protein kinase erbB-1.
Gene name:  EGFR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 2705 4
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.  
13
  • CuratedUniProtKB
Isoform  Iso 2   May act as an antagonist of EGF action.  
13
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Epidermal growth factor bindingdefinition[GO:0048408] silver  
  • IEAOrtholog Compara
Epidermal growth factor-activated receptor activitydefinition[GO:0005006]  
4
  • IDAUniProtKB
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
11
  • IPIIntAct
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
MAP kinase kinase kinase activitydefinition[GO:0004709]  
1
  • NASUniProtKB
Contributes to nitric-oxide synthase regulator activitydefinition[GO:0030235]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
81
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
4
  • IDAUniProtKB
Receptor signaling protein tyrosine kinase activitydefinition[GO:0004716] silver  
  • IEAInterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • IDAMGI
GO biological process 
Activation of phospholipase A2 activity by calcium-mediated signalingdefinition[GO:0043006]  
1
  • TASUniProtKB
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • TASUniProtKB
Alkanesulfonate metabolic processdefinition[GO:0019694] silver  
  • IEAOrtholog Compara
Astrocyte activationdefinition[GO:0048143] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDAMGI
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
  • IEAOrtholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
  • ISSOrtholog Curator
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • IDAUniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Cerebral cortex cell migrationdefinition[GO:0021795] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Diterpenoid metabolic processdefinition[GO:0016101] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
2
  • IDAUniProtKB
  • IDAMGI
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Hydrogen peroxide metabolic processdefinition[GO:0042743] silver  
  • IEAOrtholog Compara
Learning or memorydefinition[GO:0007611]  
  • ISSOrtholog Curator
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Magnesium ion homeostasisdefinition[GO:0010960] silver  
  • IEAOrtholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • NASGOC
Morphogenesis of an epithelial folddefinition[GO:0060571] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of mitotic cell cycledefinition[GO:0045930] silver  
  • IEAOrtholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IDAUniProtKB
Ossificationdefinition[GO:0001503]  
1
  • NASUniProtKB
Ovulation cycledefinition[GO:0042698] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
4
  • IDAGOC
Polysaccharide metabolic processdefinition[GO:0005976] silver  
  • IEAOrtholog Compara
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • IMPBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAMGI
Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycledefinition[GO:0031659]  
1
  • IDABHF-UCL
Positive regulation of DNA repairdefinition[GO:0045739]  
1
  • IDAUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IDAUniProtKB
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
  • IEAOrtholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729] silver