PGK1 - Phosphoglycerate kinase 1 - human protein (Function)
 
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Protein
Gene
References

 
PGK1 »  Phosphoglycerate kinase 1   [ EC 2.7.2.3 ]
 
Protein also known as:  Cell migration-inducing gene 10 protein.
Gene name:  PGK1
Entry whose protein(s) existence is based on evidence at protein level
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1 94 1
GENE REF ISO

Function

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Overview 
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • ISSOrtholog Curator
Phosphoglycerate kinase activitydefinition[GO:0004618]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Glycolytic processdefinition[GO:0006096]  
  • IEAUniPathway
Phosphorylationdefinition[GO:0016310]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.2.3: ATP + 3-phospho-D-glycerate ADP + 3-phospho-D-glyceroyl phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+5230  
Metabolic pathways  hsa01100+5230  
According to Reactome, this protein belongs to the following pathways:
Gluconeogenesis  REACT_1520  
Glycolysis  REACT_1383  
 
More information is available from:
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00558
Other
GeneWiki: PGK1
GenomeRNAi: 5230
PRO: PR:P00558