AK1 - Adenylate kinase isoenzyme 1 - human protein (Function)
 
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AK1 »  Adenylate kinase isoenzyme 1   [ EC 2.7.4.3EC 2.7.4.6 ]  (AK 1)
 
Protein also known as:  Adenylate monophosphate kinase.
Gene name:  AK1
Family name: Adenylate kinase » AK1
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  
1
  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • IDAUniProtKB
GO biological process 
ADP biosynthetic processdefinition[GO:0006172]  
  • IEAUniProtKB Annot
AMP metabolic processdefinition[GO:0046033]  
  • IEAUniProtKB Annot
ATP metabolic processdefinition[GO:0046034]  
  • IEAUniProtKB Annot
Cell cycle arrestdefinition[GO:0007050] silver  
  • IEAOrtholog Compara
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • IDAUniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.3: ATP + AMP 2 ADP.  
1
  • CuratedUniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+203  
Purine metabolism  hsa00230+203  
According to Reactome, this protein belongs to the following pathway:
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00568
Other
GenomeRNAi: 203
PRO: PR:P00568