C1R - Complement C1r subcomponent - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
C1R »  Complement C1r subcomponent   [ EC 3.4.21.41 ]
 
Protein also known as:  Complement component 1 subcomponent r. Cleaved into:  Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain.
Gene name:  C1R
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 1
GENE REF ISO

Function

 show evidences
Overview 
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.41: Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+715  
Pertussis  hsa05133+715  
Phagosome  hsa04145+715  
Staphylococcus aureus infection  hsa05150+715  
Systemic lupus erythematosus  hsa05322+715  
According to Reactome, this protein belongs to the following pathways:
Classical antibody-mediated complement activation  REACT_7956  
Initial triggering of complement  REACT_8024  
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C1R_(gene)
GenomeRNAi: 715
PRO: PR:P00736
Chemistry
GuidetoPHARMACOLOGY: 2334