F9 - Coagulation factor IX - human protein (Function)
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F9 »  Coagulation factor IX   [ EC ]
Protein also known as:  Plasma thromboplastin component (PTC). Cleaved into:  Coagulation factor IXa heavy chain; Coagulation factor IXa light chain.
Gene name:  F9
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2158  
According to Reactome, this protein belongs to the following pathways:
Extrinsic Pathway  REACT_1573  
Gamma-carboxylation of protein precursors  REACT_1050  
Intrinsic Pathway  REACT_326  
Removal of aminoterminal propeptides from gamma-carboxylated proteins  REACT_733  
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus  REACT_1906  
In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.  
  • CuratedUniProtKB


Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P00740
GeneWiki: Factor_IX
GenomeRNAi: 2158
PRO: PR:P00740