F10 - Coagulation factor X - human protein (Function)
 
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F10 »  Coagulation factor X   [ EC 3.4.21.6 ]
 
Protein also known as:  Stuart-Prower factor. Cleaved into:  Activated factor Xa heavy chain; Factor X heavy chain; Factor X light chain.
Gene name:  F10
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 265 1
GENE REF ISO

Function

 show evidences
Overview 
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • IDABHF-UCL
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • ICBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • TASBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.6: Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5 and SERPINA10.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2159  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism of proteins  REACT_17015  
 
More information is available from:
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00742
Other
GeneWiki: Factor_X
GenomeRNAi: 2159
PRO: PR:P00742
Chemistry
GuidetoPHARMACOLOGY: 2359