CFD - Complement factor D - human protein (Function)
 
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CFD »  Complement factor D   [ EC 3.4.21.46 ]
 
Protein also known as:  C3 convertase activator.
Gene name:  CFD
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.  
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.46: Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+1675  
Staphylococcus aureus infection  hsa05150+1675  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1675
PRO: PR:P00746