PLG - Plasminogen - human protein (Function)
 
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PLG »  Plasminogen   [ EC 3.4.21.7 ]
 
Cleaved into:  Activation peptide; Angiostatin; Plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B.
Gene name:  PLG
Family name: Peptidase S1 » Plasminogen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.  
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  • CuratedUniProtKB
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.  
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  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
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  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
  • IPIBHF-UCL
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • IDABHF-UCL
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASAgBase
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • IMPHGNC
Extracellular matrix disassemblydefinition[GO:0022617]  
1
  • IDABHF-UCL
Labyrinthine layer blood vessel developmentdefinition[GO:0060716] silver  
  • IEAOrtholog Compara
Mononuclear cell migrationdefinition[GO:0071674] silver  
  • IEAOrtholog Compara
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Myoblast differentiationdefinition[GO:0045445] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of cell-cell adhesion mediated by cadherindefinition[GO:2000048]  
1
  • TASBHF-UCL
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
1
  • IDABHF-UCL
Negative regulation of fibrinolysisdefinition[GO:0051918]  
1
  • IDABHF-UCL
Positive regulation of fibrinolysisdefinition[GO:0051919]  
1
  • IDABHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603] silver  
  • IEAOrtholog Compara
Tissue regenerationdefinition[GO:0042246] silver  
  • IEAOrtholog Compara
Tissue remodelingdefinition[GO:0048771]  
  • IEAUniProtKB KW
Trophoblast giant cell differentiationdefinition[GO:0060707] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.7: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+5340  
Influenza A  hsa05164+5340  
Neuroactive ligand-receptor interaction  hsa04080+5340  
Staphylococcus aureus infection  hsa05150+5340  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Degradation of the extracellular matrix  REACT_118572  
Dissolution of Fibrin Clot  REACT_641  
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)  REACT_15428  
Signaling by PDGF  REACT_16888  
 
More information is available from:
Note 
Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Fibrinolysis  definition   [KW-0280]
Hemostasis  definition   [KW-0356]
Tissue remodeling  definition   [KW-0797]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00747
Other
GeneWiki: Plasmin
GeneWiki: Plasminogen_activator
GenomeRNAi: 5340
PRO: PR:P00747
Chemistry
GuidetoPHARMACOLOGY: 2394