F12 - Coagulation factor XII - human protein (Function)
 
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F12 »  Coagulation factor XII
 
Cleaved into:  Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain.
Gene name:  F12
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 108 1
GENE REF ISO

Function

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Overview 
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.  
1
  • CuratedUniProtKB
GO molecular function 
Misfolded protein bindingdefinition[GO:0051787]  
1
  • ICBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Serine-type aminopeptidase activitydefinition[GO:0070009] silver  
  • IEAOrtholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDABHF-UCL
GO biological process 
Blood coagulation, intrinsic pathwaydefinition[GO:0007597]  
1
  • ICBHF-UCL
Factor XII activationdefinition[GO:0002542]  
1
  • IDABHF-UCL
Fibrinolysisdefinition[GO:0042730]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
1
  • TASBHF-UCL
Plasma kallikrein-kinin cascadedefinition[GO:0002353]  
2
  • IDABHF-UCL
Positive regulation of blood coagulationdefinition[GO:0030194]  
1
  • IDABHF-UCL
Positive regulation of fibrinolysisdefinition[GO:0051919]  
1
  • IDABHF-UCL
Positive regulation of plasminogen activationdefinition[GO:0010756]  
1
  • IDABHF-UCL
Protein autoprocessingdefinition[GO:0016540]  
1
  • IDABHF-UCL
Protein processingdefinition[GO:0016485]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Response to misfolded proteindefinition[GO:0051788]  
1
  • IDABHF-UCL
Zymogen activationdefinition[GO:0031638]  
3
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.38: Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2161  
According to Reactome, this protein belongs to the following pathway:
Intrinsic Pathway  REACT_326  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Fibrinolysis  definition   [KW-0280]
Hemostasis  definition   [KW-0356]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Factor_XII
GenomeRNAi: 2161
PRO: PR:P00748
Chemistry
GuidetoPHARMACOLOGY: 2361