PLAU - Urokinase-type plasminogen activator - human protein (Function)
 
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PLAU »  Urokinase-type plasminogen activator   [ EC 3.4.21.73 ]  (uPA)
 
Cleaved into:  Urokinase-type plasminogen activator chain B; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A.
Gene name:  PLAU
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 403 2
GENE REF ISO

Function

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Overview 
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
GO biological process 
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of cell adhesion mediated by integrindefinition[GO:0033628]  
1
  • IDABHF-UCL
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of receptor activitydefinition[GO:0010469]  
1
  • IDABHF-UCL
Regulation of smooth muscle cell migrationdefinition[GO:0014910]  
1
  • IDABHF-UCL
Regulation of smooth muscle cell-matrix adhesiondefinition[GO:2000097]  
1
  • IDABHF-UCL
Regulation of wound healingdefinition[GO:0061041]  
1
  • ICBHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Smooth muscle cell migrationdefinition[GO:0014909] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.73: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+5328  
According to Reactome, this protein belongs to the following pathway:
Dissolution of Fibrin Clot  REACT_641  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Fibrinolysis  definition   [KW-0280]
Hemostasis  definition   [KW-0356]
Plasminogen activation  definition   [KW-0617]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00749
Other
GeneWiki: PLAU
GenomeRNAi: 5328
PRO: PR:P00749
Chemistry
GuidetoPHARMACOLOGY: 2393