CFB - Complement factor B - human protein (Function)
 
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CFB »  Complement factor B   [ EC 3.4.21.47 ]
 
Protein also known as:  Glycine-rich beta glycoprotein (GBG). Cleaved into:  Complement factor B Ba fragment; Complement factor B Bb fragment.
Gene name:  CFB
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 70 2
GENE REF ISO

Function

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Overview 
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.  
  • CuratedUniProtKB
GO molecular function 
Complement bindingdefinition[GO:0001848]  
1
  • TASUniProtKB
GO biological process 
Complement activation, alternative pathwaydefinition[GO:0006957]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.47: Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+629  
Staphylococcus aureus infection  hsa05150+629  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Complement_factor_B
GenomeRNAi: 629
PRO: PR:P00751