REN - Renin - human protein (Function)
 
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REN »  Renin   [ EC 3.4.23.15 ]
 
Protein also known as:  Angiotensinogenase.
Gene name:  REN
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
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1 161 2
GENE REF ISO

Function

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Overview 
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.  
  • CuratedUniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
1
  • IDAHGNC
Insulin-like growth factor receptor bindingdefinition[GO:0005159] silver  
  • IEAOrtholog Compara
Peptidase activitydefinition[GO:0008233]  
1
  • IDAHGNC
Receptor bindingdefinition[GO:0005102]  
1
  • IPIHGNC
GO biological process 
Angiotensin maturationdefinition[GO:0002003]  
1
  • IDAHGNC
Beta-amyloid metabolic processdefinition[GO:0050435] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Drinking behaviordefinition[GO:0042756] silver  
  • IEAOrtholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822]  
1
  • IMPBHF-UCL
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Mesonephros developmentdefinition[GO:0001823] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IDAHGNC
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • IDAHGNC
Renin-angiotensin regulation of aldosterone productiondefinition[GO:0002018] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to cGMPdefinition[GO:0070305] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.15: Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.  
  • CuratedUniProtKB
It is regulated in the following manner
Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renin-angiotensin system  hsa04614+5972  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Biophysicochemical properties

Kinetic parameters
KM 1 uM for angiotensinogen (in absence of ATP6AP2)
KM 0.15 uM for angiotensinogen (in presence of membrane-bound ATP6AP2)

Keywords

Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Renin
GenomeRNAi: 5972
PRO: PR:P00797
Chemistry
GuidetoPHARMACOLOGY: 2413