ADA - Adenosine deaminase - human protein (Function)
 
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ADA »  Adenosine deaminase   [ EC 3.5.4.4 ]
 
Protein also known as:  Adenosine aminohydrolase.
Gene name:  ADA
Entry whose protein(s) existence is based on evidence at protein level
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1 132 1
GENE REF ISO

Function

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Overview 
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.  
1
  • CuratedUniProtKB
GO molecular function 
Adenosine deaminase activitydefinition[GO:0004000]  
6
  • IDAUniProtKB
  • IDAMGI
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Purine nucleoside bindingdefinition[GO:0001883] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
GO biological process 
Adenosine catabolic processdefinition[GO:0006154]  
2
  • IDAUniProtKB
  • IDAMGI
  • ISSOrtholog Curator
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
dATP catabolic processdefinition[GO:0046061] silver  
  • IEAOrtholog Compara
Deoxyadenosine catabolic processdefinition[GO:0006157] silver  
  • IEAOrtholog Compara
Embryonic digestive tract developmentdefinition[GO:0048566] silver  
  • IEAOrtholog Compara
Germinal center B cell differentiationdefinition[GO:0002314] silver  
  • IEAOrtholog Compara
Histamine secretiondefinition[GO:0001821] silver  
  • IEAOrtholog Compara
Hypoxanthine salvagedefinition[GO:0043103] silver  
  • IBARefGenome
Inosine biosynthetic processdefinition[GO:0046103]  
1
  • IDAMGI
  • ISSOrtholog Curator
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IEAOrtholog Compara
Negative regulation of adenosine receptor signaling pathwaydefinition[GO:0060169]  
1
  • IDAUniProtKB
Negative regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0042323] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of leukocyte migrationdefinition[GO:0002686] silver  
  • IEAOrtholog Compara
Negative regulation of mature B cell apoptotic processdefinition[GO:0002906] silver  
  • IEAOrtholog Compara
Negative regulation of mucus secretiondefinition[GO:0070256] silver  
  • IEAOrtholog Compara
Negative regulation of penile erectiondefinition[GO:0060407] silver  
  • IEAOrtholog Compara
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244] silver  
  • IEAOrtholog Compara
Peyer's patch developmentdefinition[GO:0048541] silver  
  • IEAOrtholog Compara
Placenta developmentdefinition[GO:0001890] silver  
  • IEAOrtholog Compara
Positive regulation of alpha-beta T cell differentiationdefinition[GO:0046638] silver  
  • IEAOrtholog Compara
Positive regulation of B cell proliferationdefinition[GO:0030890] silver  
  • IEAOrtholog Compara
Positive regulation of calcium-mediated signalingdefinition[GO:0050850] silver  
  • IEAOrtholog Compara
Positive regulation of germinal center formationdefinition[GO:0002636] silver  
  • IEAOrtholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle contractiondefinition[GO:0045987] silver  
  • IEAOrtholog Compara
Positive regulation of T cell differentiation in thymusdefinition[GO:0033089] silver  
  • IEAOrtholog Compara
Positive regulation of T cell receptor signaling pathwaydefinition[GO:0050862] silver  
  • IEAOrtholog Compara
Purine nucleotide salvagedefinition[GO:0032261]  
1
  • IMPUniProtKB
Purine ribonucleoside monophosphate biosynthetic processdefinition[GO:0009168] silver  
  • IEAInterPro 2 GO
Regulation of cell-cell adhesion mediated by integrindefinition[GO:0033632]  
1
  • IDAUniProtKB
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
T cell activationdefinition[GO:0042110]  
1
  • IDAUniProtKB
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
  • IEAOrtholog Compara
Xanthine biosynthetic processdefinition[GO:0046111] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.4.4: Adenosine + H(2)O inosine + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+100  
Primary immunodeficiency  hsa05340+100  
Purine metabolism  hsa00230+100  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Nucleotide metabolism  definition   [KW-0546]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00813
Other
GeneWiki: Adenosine_deaminase
GenomeRNAi: 100
PRO: PR:P00813
Chemistry
GuidetoPHARMACOLOGY: 1230