MT-ATP6 - ATP synthase subunit a - human protein (Function)
 
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MT-ATP6 »  ATP synthase subunit a
 
Protein also known as:  F-ATPase protein 6.
Gene name:  MT-ATP6
Family name: ATPase A chain
Entry whose protein(s) existence is based on evidence at protein level
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1 30 1
GENE REF ISO

Function

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Overview 
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.  
  • CuratedUniProtKB
GO molecular function 
Contributes to ATPase activitydefinition[GO:0016887]  
1
  • IDAUniProtKB
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
Transmembrane transporter activitydefinition[GO:0022857]  
1
  • ICUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Mitochondrial ATP synthesis coupled proton transportdefinition[GO:0042776]  
1
  • ICUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4508  
Huntington's disease  hsa05016+4508  
Metabolic pathways  hsa01100+4508  
Oxidative phosphorylation  hsa00190+4508  
Parkinson's disease  hsa05012+4508  
According to Reactome, this protein belongs to the following pathway:
Formation of ATP by chemiosmotic coupling  REACT_6759  
 

Keywords

Biological process 
ATP synthesis  definition   [KW-0066]
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MT-ATP6
GenomeRNAi: 4508
PRO: PR:P00846