CA1 - Carbonic anhydrase 1 - human protein (Function)
 
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Protein
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CA1 »  Carbonic anhydrase 1   [ EC 4.2.1.1 ]
 
Protein also known as:  Carbonate dehydratase I.
Gene name:  CA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.  
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  • CuratedUniProtKB
GO molecular function 
Carbonate dehydratase activitydefinition[GO:0004089]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by histamine, imidazole, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide), and 'prong inhibitors' BR15, BR17, BR22 and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one. Esterase activity weakly reduced by cyanamide.  
9
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nitrogen metabolism  hsa00910+759  
According to Reactome, this protein belongs to the following pathways:
Erythrocytes take up carbon dioxide and release oxygen  REACT_121329  
Erythrocytes take up oxygen and release carbon dioxide  REACT_121380  
Reversible hydration of carbon dioxide  REACT_121123  
 

Biophysicochemical properties

Kinetic parameters
KM 4.0 mM for CO(2)
KM 15 mM for 4-nitrophenyl acetate

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00915
Other
GeneWiki: CA1_(gene)
GenomeRNAi: 759
PRO: PR:P00915
Chemistry
GuidetoPHARMACOLOGY: 2597