ASS1 - Argininosuccinate synthase - human protein (Function)
 
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Protein
Gene
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ASS1 »  Argininosuccinate synthase   [ EC 6.3.4.5 ]
 
Protein also known as:  Citrulline--aspartate ligase.
Gene name:  ASS1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Is indirectly involved in the control of blood pressure.  
1
  • UniProtKB
GO molecular function 
Amino acid bindingdefinition[GO:0016597]  
1
  • BHF-UCL
Argininosuccinate synthase activitydefinition[GO:0004055]  
1
  • BHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Toxic substance bindingdefinition[GO:0015643] silver  
1
  • Ortholog Compara
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Arginine biosynthetic processdefinition[GO:0006526]  
2
  • UniPathway
  • RefGenome
Argininosuccinate metabolic processdefinition[GO:0000053]  
1
  • BHF-UCL
Aspartate metabolic processdefinition[GO:0006531]  
1
  • BHF-UCL
Cellular response to amine stimulusdefinition[GO:0071418] silver  
1
  • Ortholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Cellular response to ammonium iondefinition[GO:0071242] silver  
1
  • Ortholog Compara
Cellular response to cAMPdefinition[GO:0071320] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to glucagon stimulusdefinition[GO:0071377] silver  
1
  • Ortholog Compara
Cellular response to interferon-gammadefinition[GO:0071346] silver  
1
  • Ortholog Compara
Cellular response to laminar fluid shear stressdefinition[GO:0071499]  
1
  • BHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to oleic aciddefinition[GO:0071400] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Citrulline metabolic processdefinition[GO:0000052]  
1
  • BHF-UCL
Diaphragm developmentdefinition[GO:0060539] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Midgut developmentdefinition[GO:0007494] silver  
1
  • Ortholog Compara
Negative regulation of leukocyte cell-cell adhesiondefinition[GO:1903038]  
1
  • BHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • BHF-UCL
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to growth hormonedefinition[GO:0060416] silver  
1
  • Ortholog Compara
Response to mycotoxindefinition[GO:0010046] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to zinc iondefinition[GO:0010043] silver  
1
  • Ortholog Compara
Urea cycledefinition[GO:0000050]  
2
  • BHF-UCL
  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.5: ATP + L-citrulline + L-aspartate AMP + diphosphate + N(omega)-(L-arginino)succinate.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathways
Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3  
1
  • UniProtKB
Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+445  
Arginine and proline metabolism  hsa00330+445  
Metabolic pathways  hsa01100+445  
According to Reactome, this protein belongs to the following pathway:
Urea cycle  REACT_847  
 
More information is available from:
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Arginine biosynthesis  definition   [KW-0055]
Urea cycle  definition   [KW-0835]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P00966
Other
GeneWiki: Argininosuccinate_synthetase_1
GenomeRNAi: 445
PRO: PR:P00966