SPINK1 - Serine protease inhibitor Kazal-type 1 - human protein (Function)
 
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SPINK1 »  Serine protease inhibitor Kazal-type 1
 
Protein also known as:  Pancreatic secretory trypsin inhibitor.
Gene name:  SPINK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine protease inhibitor which exhibits anti-trypsin activity (PubMed7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).  
3
  • UniProtKB
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.  
2
  • UniProtKB
GO molecular function 
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • RefGenome
GO biological process 
Negative regulation of calcium ion importdefinition[GO:0090281] silver  
1
  • Ortholog Compara
Negative regulation of nitric oxide mediated signal transductiondefinition[GO:0010751] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732] silver  
1
  • Ortholog Compara
Negative regulation of serine-type endopeptidase activitydefinition[GO:1900004]  
1
  • RefGenome
Regulation of acrosome reactiondefinition[GO:0060046]  
1
  • RefGenome
Regulation of store-operated calcium entrydefinition[GO:2001256] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPINK1
GenomeRNAi: 6690
PRO: PR:P00995