SPINK1 - Pancreatic secretory trypsin inhibitor - human protein (Function)
 
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SPINK1 »  Pancreatic secretory trypsin inhibitor
 
Gene name:  SPINK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.  
  • CuratedUniProtKB
GO molecular function 
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of calcium ion importdefinition[GO:0090281] silver  
  • IEAOrtholog Compara
Negative regulation of nitric oxide mediated signal transductiondefinition[GO:0010751] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732] silver  
  • IEAOrtholog Compara
Negative regulation of serine-type endopeptidase activitydefinition[GO:1900004] silver  
  • IEAOrtholog Compara
Regulation of acrosome reactiondefinition[GO:0060046] silver  
  • IEAOrtholog Compara
Regulation of store-operated calcium entrydefinition[GO:2001256] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPINK1
GenomeRNAi: 6690
PRO: PR:P00995