SERPINC1 - Antithrombin-III - human protein (Function)
 
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SERPINC1 »  Antithrombin-III  (ATIII)
 
Protein also known as:  Serpin C1.
Gene name:  SERPINC1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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1 161 1
GENE REF ISO

Function

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Overview 
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.  
1
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • NASUniProtKB
  • IBARefGenome
GO biological process 
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Regulation of blood coagulation, intrinsic pathwaydefinition[GO:2000266] silver  
  • IEAInterPro 2 GO
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+462  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Antithrombin
GenomeRNAi: 462
PRO: PR:P01008
Chemistry
GuidetoPHARMACOLOGY: 2632