SERPINA1 - Alpha-1-antitrypsin - human protein (Function)
 
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SERPINA1 »  Alpha-1-antitrypsin
 
Protein also known as:  Alpha-1 protease inhibitor. Cleaved into:  Short peptide from AAT.
Gene name:  SERPINA1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.  
3
  • CuratedUniProtKB
Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).  
3
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
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  • IPIIntAct
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIUniProtKB
  • IPIIntAct
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
2
  • IDAMGI
  • NASUniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
  • IEAUniProtKB KW
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+5265  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
Note 
The aberrant form is found in the plasma of chronic smokers, and persists after smoking is ceased. It can still be found ten years after smoking has ceased.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Alpha_1-antitrypsin
GenomeRNAi: 5265
PRO: PR:P01009