AGT - Angiotensinogen - human protein (Function)
 
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AGT »  Angiotensinogen
 
Protein also known as:  Serpin A8. Cleaved into:  Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-9; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4.
Gene name:  AGT
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.  
1
  • UniProtKB
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.  
1
  • UniProtKB
Angiotensin-3: stimulates aldosterone release.  
1
  • UniProtKB
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.  
1
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • BHF-UCL
Hormone activitydefinition[GO:0005179]  
2
  • BHF-UCL
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • AgBase
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • PINC
Sodium channel regulator activitydefinition[GO:0017080]  
2
  • BHF-UCL
Superoxide-generating NADPH oxidase activator activitydefinition[GO:0016176]  
1
  • BHF-UCL
Type 1 angiotensin receptor bindingdefinition[GO:0031702]  
1
  • BHF-UCL
Type 2 angiotensin receptor bindingdefinition[GO:0031703]  
1
  • BHF-UCL
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250] silver  
1
  • Ortholog Compara
Activation of phospholipase C activitydefinition[GO:0007202] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressuredefinition[GO:0001998] silver  
1
  • Ortholog Compara
Angiotensin-mediated drinking behaviordefinition[GO:0003051] silver  
1
  • Ortholog Compara
Artery smooth muscle contractiondefinition[GO:0014824] silver  
1
  • Ortholog Compara
Astrocyte activationdefinition[GO:0048143] silver  
1
  • Ortholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974]  
1
  • BHF-UCL
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Catenin import into nucleusdefinition[GO:0035411] silver  
1
  • Ortholog Compara
Cell growth involved in cardiac muscle cell developmentdefinition[GO:0061049] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cell-matrix adhesiondefinition[GO:0007160] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
1
  • Ortholog Compara
Cellular sodium ion homeostasisdefinition[GO:0006883] silver  
1
  • Ortholog Compara
Cytokine secretiondefinition[GO:0050663] silver  
1
  • Ortholog Compara
ERK1 and ERK2 cascadedefinition[GO:0070371] silver  
1
  • Ortholog Compara
Establishment of blood-nerve barrierdefinition[GO:0008065] silver  
1
  • Ortholog Compara
Excretiondefinition[GO:0007588] silver  
1
  • Ortholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Fibroblast proliferationdefinition[GO:0048144] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • BHF-UCL
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199]  
1
  • BHF-UCL
Kidney developmentdefinition[GO:0001822]  
1
  • BHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • BHF-UCL
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • RefGenome
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of neurotrophin TRK receptor signaling pathwaydefinition[GO:0051387]  
1
  • BHF-UCL
Negative regulation of sodium ion transmembrane transporter activitydefinition[GO:2000650]  
1
  • BHF-UCL
Negative regulation of tissue remodelingdefinition[GO:0034104] silver  
1
  • Ortholog Compara
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • BHF-UCL
Ovarian follicle rupturedefinition[GO:0001543] silver  
1
  • Ortholog Compara
Peristalsisdefinition[GO:0030432] silver  
1
  • Ortholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • BHF-UCL
Positive regulation of activation of JAK2 kinase activitydefinition[GO:0010535]  
1
  • UniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
1
  • UniProtKB
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613]  
1
  • Ortholog Curator
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • BHF-UCL
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • BHF-UCL
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • BHF-UCL
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • BHF-UCL
Positive regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0045742]  
1
  • BHF-UCL
Positive regulation of extracellular matrix constituent secretiondefinition[GO:0003331] silver  
1
  • Ortholog Compara
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • BHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • Ortholog Curator
Positive regulation of gap junction assemblydefinition[GO:1903598]  
1
  • BHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
2
  • BHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
1
  • Ortholog Compara
Positive regulation of membrane hyperpolarizationdefinition[GO:1902632]  
2
  • BHF-UCL
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Positive regulation of NAD(P)H oxidase activitydefinition[GO:0033864]  
2
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • BHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
1
  • Ortholog Compara
Positive regulation of organ growthdefinition[GO:0046622] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • BHF-UCL
Positive regulation of protein kinase C activitydefinition[GO:1900020] silver  
1
  • Ortholog Compara
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • UniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • BHF-UCL
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
1
  • Ortholog Compara
Positive regulation of superoxide anion generationdefinition[GO:0032930] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
Positive regulation of vasodilationdefinition[GO:0045909] silver  
1
  • Ortholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
1
  • BHF-UCL
Regulation of blood vessel size by renin-angiotensindefinition[GO:0002034]  
1
  • BHF-UCL
Regulation of blood volume by renin-angiotensindefinition[GO:0002016]  
1
  • BHF-UCL
Regulation of calcium ion transportdefinition[GO:0051924] silver  
1
  • Ortholog Compara
Regulation of cardiac conductiondefinition[GO:1903779]  
1
  • BHF-UCL
Regulation of cell growthdefinition[GO:0001558]  
1
  • BHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • BHF-UCL
Regulation of extracellular matrix assemblydefinition[GO:1901201]  
1
  • BHF-UCL
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Regulation of norepinephrine secretiondefinition[GO:0014061] silver  
1
  • Ortholog Compara
Regulation of renal output by angiotensindefinition[GO:0002019]  
1
  • BHF-UCL
Regulation of renal sodium excretiondefinition[GO:0035813]  
1
  • BHF-UCL
Regulation of transmission of nerve impulsedefinition[GO:0051969] silver  
1
  • Ortholog Compara
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • BHF-UCL
Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressuredefinition[GO:0001999] silver  
1
  • Ortholog Compara
Renal system processdefinition[GO:0003014]  
1
  • UniProtKB
Renin-angiotensin regulation of aldosterone productiondefinition[GO:0002018]  
1
  • BHF-UCL
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to muscle activity involved in regulation of muscle adaptationdefinition[GO:0014873]  
1
  • Ortholog Curator
Response to salt stressdefinition[GO:0009651] silver  
1
  • Ortholog Compara
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
1
  • Ortholog Compara
Smooth muscle cell proliferationdefinition[GO:0048659] silver  
1
  • Ortholog Compara
Stress-activated MAPK cascadedefinition[GO:0051403] silver  
1
  • Ortholog Compara
Uterine smooth muscle contractiondefinition[GO:0070471] silver  
1
  • Ortholog Compara
Vasodilationdefinition[GO:0042311] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renin-angiotensin system  hsa04614+183  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
Peptide ligand-binding receptors  REACT_14819  
PPARA activates gene expression  REACT_116145  
 

Keywords

Molecular function 
Vasoactive  definition   [KW-0838]
Vasoconstrictor  definition   [KW-0839]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiotensin
GenomeRNAi: 183
PRO: PR:P01019