AGT - Angiotensinogen - human protein (Function)
 
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AGT »  Angiotensinogen
 
Protein also known as:  Serpin A8. Cleaved into:  Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-9; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4.
Gene name:  AGT
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.  
3
  • CuratedUniProtKB
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.  
3
  • CuratedUniProtKB
Angiotensin-3: stimulates aldosterone release.  
3
  • CuratedUniProtKB
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).  
3
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • TASBHF-UCL
Hormone activitydefinition[GO:0005179]  
1
  • ICBHF-UCL
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IBARefGenome
Type 1 angiotensin receptor bindingdefinition[GO:0031702]  
1
  • IPIBHF-UCL
Type 2 angiotensin receptor bindingdefinition[GO:0031703]  
1
  • IPIBHF-UCL
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250] silver  
  • IEAOrtholog Compara
Activation of phospholipase C activitydefinition[GO:0007202] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressuredefinition[GO:0001998] silver  
  • IEAOrtholog Compara
Angiotensin-mediated drinking behaviordefinition[GO:0003051] silver  
  • IEAOrtholog Compara
Artery smooth muscle contractiondefinition[GO:0014824] silver  
  • IEAOrtholog Compara
Astrocyte activationdefinition[GO:0048143] silver  
  • IEAOrtholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Blood vessel remodelingdefinition[GO:0001974]  
1
  • TASBHF-UCL
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Catenin import into nucleusdefinition[GO:0035411] silver  
  • IEAOrtholog Compara
Cell growth involved in cardiac muscle cell developmentdefinition[GO:0061049] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cell-matrix adhesiondefinition[GO:0007160] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Cellular sodium ion homeostasisdefinition[GO:0006883] silver  
  • IEAOrtholog Compara
Cytokine secretiondefinition[GO:0050663] silver  
  • IEAOrtholog Compara
ERK1 and ERK2 cascadedefinition[GO:0070371] silver  
  • IEAOrtholog Compara
Establishment of blood-nerve barrierdefinition[GO:0008065] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588] silver  
  • IEAOrtholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Fibroblast proliferationdefinition[GO:0048144] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199]  
1
  • TASBHF-UCL
Kidney developmentdefinition[GO:0001822]  
1
  • IMPBHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • NASBHF-UCL
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of neurotrophin TRK receptor signaling pathwaydefinition[GO:0051387]  
1
  • IDABHF-UCL
Negative regulation of tissue remodelingdefinition[GO:0034104] silver  
  • IEAOrtholog Compara
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • TASBHF-UCL
Ovarian follicle rupturedefinition[GO:0001543] silver  
  • IEAOrtholog Compara
Peristalsisdefinition[GO:0030432] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • NASBHF-UCL
Positive regulation of activation of JAK2 kinase activitydefinition[GO:0010535]  
1
  • IMPUniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
1
  • IDAUniProtKB
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613]  
  • ISSOrtholog Curator
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IDABHF-UCL
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • IDABHF-UCL
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • TASBHF-UCL
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDABHF-UCL
Positive regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0045742]  
1
  • IDABHF-UCL
Positive regulation of extracellular matrix constituent secretiondefinition[GO:0003331] silver  
  • IEAOrtholog Compara
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IDABHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
  • ISSOrtholog Curator
Positive regulation of inflammatory responsedefinition[GO:0050729]  
2
  • TASBHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • ICBHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
  • IEAOrtholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of NAD(P)H oxidase activitydefinition[GO:0033864]  
1
  • TASBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • TASBHF-UCL
Positive regulation of organ growthdefinition[GO:0046622] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDABHF-UCL
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • IMPUniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • TASBHF-UCL
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of superoxide anion generationdefinition[GO:0032930] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
Regulation of blood vessel size by renin-angiotensindefinition[GO:0002034]  
1
  • TASBHF-UCL
Regulation of blood volume by renin-angiotensindefinition[GO:0002016]  
1
  • NASBHF-UCL
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of cell growthdefinition[GO:0001558]  
1
  • NASBHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • NASBHF-UCL
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
  • IEAOrtholog Compara
Regulation of norepinephrine secretiondefinition[GO:0014061] silver  
  • IEAOrtholog Compara
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Regulation of renal output by angiotensindefinition[GO:0002019]  
1
  • NASBHF-UCL
Regulation of renal sodium excretiondefinition[GO:0035813]  
1
  • NASBHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • NASBHF-UCL
Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressuredefinition[GO:0001999] silver  
  • IEAOrtholog Compara
Renal system processdefinition[GO:0003014]  
1
  • IDAUniProtKB
Renin-angiotensin regulation of aldosterone productiondefinition[GO:0002018]  
1
  • NASBHF-UCL
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to muscle activity involved in regulation of muscle adaptationdefinition[GO:0014873]  
  • ISSOrtholog Curator
Response to salt stressdefinition[GO:0009651] silver  
  • IEAOrtholog Compara
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
  • IEAOrtholog Compara
Smooth muscle cell proliferationdefinition[GO:0048659] silver  
  • IEAOrtholog Compara
Stress-activated MAPK cascadedefinition[GO:0051403] silver  
  • IEAOrtholog Compara
Uterine smooth muscle contractiondefinition[GO:0070471] silver  
  • IEAOrtholog Compara
Vasodilationdefinition[GO:0042311] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renin-angiotensin system  hsa04614+183  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Vasoactive  definition   [KW-0838]
Vasoconstrictor  definition   [KW-0839]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiotensin
GenomeRNAi: 183
PRO: PR:P01019