A2M - Alpha-2-macroglobulin - human protein (Function)
 
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A2M »  Alpha-2-macroglobulin  (Alpha-2-M)
 
Protein also known as:  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5.
Gene name:  A2M
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.  
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  • UniProtKB
GO molecular function 
Calcium-dependent protein bindingdefinition[GO:0048306]  
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  • AgBase
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Growth factor bindingdefinition[GO:0019838]  
1
  • UniProtKB
Interleukin-1 bindingdefinition[GO:0019966]  
1
  • UniProtKB
Interleukin-8 bindingdefinition[GO:0019959]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • AgBase
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • AgBase
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • UniProtKB
Tumor necrosis factor bindingdefinition[GO:0043120]  
1
  • UniProtKB
GO biological process 
Negative regulation of complement activation, lectin pathwaydefinition[GO:0001869]  
1
  • UniProtKB
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
3
  • GOC
  • UniProtKB KW
  • InterPro 2 GO
Stem cell differentiationdefinition[GO:0048863] silver  
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  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2  
According to Reactome, this protein belongs to the following pathways:
Degradation of the extracellular matrix  REACT_118572  
HDL-mediated lipid transport  REACT_13621  
Intrinsic Pathway  REACT_326  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2
PRO: PR:P01023