C5 - Complement C5 - human protein (Function)
 
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C5 »  Complement C5
 
Protein also known as:  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4. Cleaved into:  C5a anaphylatoxin; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain.
Gene name:  C5
Entry whose protein(s) existence is based on evidence at protein level
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1 118 1
GENE REF ISO

Function

 show evidences
Overview 
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.  
  • CuratedUniProtKB
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).  
  • CuratedUniProtKB
GO molecular function 
C5a anaphylatoxin chemotactic receptor bindingdefinition[GO:0031714] silver  
  • IEAOrtholog Compara
Chemokine activitydefinition[GO:0008009]  
1
  • TASPINC
Endopeptidase inhibitor activitydefinition[GO:0004866] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Receptor bindingdefinition[GO:0005102]  
2
  • TASPINC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Cell chemotaxisdefinition[GO:0060326]  
1
  • TASGOC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Complement activation, alternative pathwaydefinition[GO:0006957]  
  • IEAUniProtKB KW
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Cytolysisdefinition[GO:0019835]  
  • IEAUniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Leukocyte migration involved in inflammatory responsedefinition[GO:0002523] silver  
  • IEAOrtholog Compara
Negative regulation of dopamine secretiondefinition[GO:0033602] silver  
  • IEAOrtholog Compara
Negative regulation of macrophage chemotaxisdefinition[GO:0010760]  
1
  • IDABHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Positive regulation of chemokine secretiondefinition[GO:0090197]  
1
  • IDABHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921] silver  
  • IEAOrtholog Compara
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
2
  • IDABHF-UCL
Response to stressdefinition[GO:0006950]  
1
  • TASPINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+727  
Herpes simplex infection  hsa05168+727  
Pertussis  hsa05133+727  
Prion diseases  hsa05020+727  
Staphylococcus aureus infection  hsa05150+727  
Systemic lupus erythematosus  hsa05322+727  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Complement pathway  definition   [KW-0180]
Cytolysis  definition   [KW-0204]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Complement_component_5
GenomeRNAi: 727
PRO: PR:P01031