C5 - Complement C5 - human protein (Function)
 
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C5 »  Complement C5
 
Protein also known as:  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4. Cleaved into:  C5a anaphylatoxin; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain.
Gene name:  C5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.  
1
  • UniProtKB
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.  
2
  • UniProtKB
GO molecular function 
C5a anaphylatoxin chemotactic receptor bindingdefinition[GO:0031714] silver  
1
  • Ortholog Compara
Chemokine activitydefinition[GO:0008009]  
1
  • PINC
Endopeptidase inhibitor activitydefinition[GO:0004866] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor bindingdefinition[GO:0005102]  
2
  • PINC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • PINC
Cell chemotaxisdefinition[GO:0060326]  
1
  • GOC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
1
  • Ortholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Complement activation, alternative pathwaydefinition[GO:0006957]  
1
  • UniProtKB KW
Complement activation, classical pathwaydefinition[GO:0006958]  
1
  • UniProtKB KW
Cytolysisdefinition[GO:0019835]  
1
  • UniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Leukocyte migration involved in inflammatory responsedefinition[GO:0002523] silver  
1
  • Ortholog Compara
Negative regulation of dopamine secretiondefinition[GO:0033602] silver  
1
  • Ortholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • InterPro 2 GO
Negative regulation of macrophage chemotaxisdefinition[GO:0010760]  
1
  • BHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
1
  • Ortholog Compara
Positive regulation of chemokine secretiondefinition[GO:0090197]  
1
  • BHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921] silver  
1
  • Ortholog Compara
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
2
  • BHF-UCL
Response to stressdefinition[GO:0006950]  
1
  • PINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+727  
Herpes simplex infection  hsa05168+727  
Pertussis  hsa05133+727  
Prion diseases  hsa05020+727  
Staphylococcus aureus infection  hsa05150+727  
Systemic lupus erythematosus  hsa05322+727  
According to Reactome, this protein belongs to the following pathways:
Activation of C3 and C5  REACT_7972  
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
Regulation of Complement cascade  REACT_118707  
Terminal pathway of complement  REACT_8028  
 
More information is available from:
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Complement pathway  definition   [KW-0180]
Cytolysis  definition   [KW-0204]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Complement_component_5
GenomeRNAi: 727
PRO: PR:P01031