CST3 - Cystatin-C - human protein (Function)
 
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CST3 »  Cystatin-C
 
Protein also known as:  Neuroendocrine basic polypeptide.
Gene name:  CST3
Family name: Cystatin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.  
  • CuratedUniProtKB
GO molecular function 
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • IPIBHF-UCL
Cysteine-type endopeptidase inhibitor activitydefinition[GO:0004869]  
2
  • IDABHF-UCL
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • IDAUniProtKB
Protease bindingdefinition[GO:0002020]  
2
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cell activationdefinition[GO:0001775] silver  
  • IEAOrtholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Circadian sleep/wake cycle, REM sleepdefinition[GO:0042747] silver  
  • IEAOrtholog Compara
Defense responsedefinition[GO:0006952]  
1
  • IDABHF-UCL
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • IGIBHF-UCL
Eye developmentdefinition[GO:0001654] silver  
  • IEAOrtholog Compara
Negative regulation of blood vessel remodelingdefinition[GO:0060313]  
1
  • IEPBHF-UCL
Negative regulation of cell deathdefinition[GO:0060548] silver  
  • IEAOrtholog Compara
Negative regulation of collagen catabolic processdefinition[GO:0010711]  
1
  • IEPBHF-UCL
Negative regulation of elastin catabolic processdefinition[GO:0060311]  
1
  • IMPBHF-UCL
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
3
  • IDAGOC
Negative regulation of extracellular matrix disassemblydefinition[GO:0010716]  
1
  • IEPBHF-UCL
Negative regulation of histolysisdefinition[GO:0010703]  
1
  • ICBHF-UCL
Negative regulation of peptidase activitydefinition[GO:0010466]  
2
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Regulation of endopeptidase activitydefinition[GO:0052548]  
3
  • IDAGOC
Regulation of programmed cell deathdefinition[GO:0043067] silver  
  • IEAOrtholog Compara
Regulation of tissue remodelingdefinition[GO:0034103]  
1
  • IEPBHF-UCL
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Salivary gland developmentdefinition[GO:0007431] silver  
  • IEAOrtholog Compara
Sertoli cell developmentdefinition[GO:0060009] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salivary secretion  hsa04970+1471  
According to Reactome, this protein belongs to the following pathway:
Disease  REACT_116125  
Note 
Potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Thiol protease inhibitor  definition   [KW-0789]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cystatin_C
GenomeRNAi: 1471
PRO: PR:P01034